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Article

Doublecortin facilitates the elongation of the somatic Golgi apparatus into proximal dendrites.

Molecular biology of the cell - 1 Mar 2021

Li Peijun, Li Luyao, Yu Binyuan, Wang Xinye, Wang Qi, Lin Jingjing, Zheng Yihui, Zhu Jinjin, He Minzhi, Xia Zhaonan, Tu Mengjing, Liu Judy S, Lin Zhenlang, Fu Xiaoqin

Abstract excerpt

Mutations in the doublecortin (DCX) gene, which encodes a microtubule (MT)-binding protein, cause human cortical malformations, including lissencephaly and subcortical band heterotopia. A deficiency in DCX and DCX-like kinase 1 (DCLK1), a functionally redundant and structurally similar cognate of DCX, decreases neurite length and increases the number of primary neurites directly arising from the soma. The...

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Identifiers

PMID: 33405953
DOI: 10.1091/mbc.E19-09-0530
PMCID: PMC8098852

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