Article

The X-linked intellectual disability gene product and E3 ubiquitin ligase KLHL15 degrades doublecortin proteins to constrain neuronal dendritogenesis

2020-10-02

Abstract excerpt

<h4>ABSTRACT</h4> Proper brain development and function requires finely controlled mechanisms for protein turnover and disruption of genes involved in proteostasis is a common cause of neurodevelopmental disorders. Kelch-like 15 (KLHL15) is a substrate adaptor for cullin3 (Cul3)-containing E3 ubiquitin ligases and KLHL15 gene mutations were recently described as a cause of severe X-linked intellectual disability...

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Literature Corpus work: 75d16642-23b0-5257-94a4-5851e35121cf
DOI: 10.1101/2020.10.02.324285

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