Article
[C677T and A1298C MTHFR polymorphisms in the etiology of neural tube defects in Spanish population].
Medicina clinica - 5 Apr 2003
Gutiérrez Revilla José Ignacio, Pérez Hernández Flora, Calvo Martín M Teresa, Tamparillas Salvador Manuel, Gracia Romero Jesús
Abstract excerpt
BACKGROUND AND OBJECTIVE: The etiology of neural tube defects (NTDs) is multifactorial. The presence of mutated genotypes of C677T and A1298C polymorphisms, and their combined heterozygosity, have been considered risk factors for the occurrence and recurrence of NTDs in some populations. SUBJECTS AND METHOD: This case-control study included 159 healthy controls, 27 NTDs patients, 28 patients' mothers and 23...
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