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Article

Correlation between checkpoint activation and in vivo assembly of the yeast checkpoint complex Rad17-Mec3-Ddc1.

The Journal of biological chemistry - 20 Jun 2003

Giannattasio Michele, Sabbioneda Simone, Minuzzo Mario, Plevani Paolo, Muzi-Falconi Marco

Abstract excerpt

Rad17-Mec3-Ddc1 forms a proliferating cell nuclear antigen-like complex that is required for the DNA damage response in Saccharomyces cerevisiae and acts at an early step of the signal transduction cascade activated by DNA lesions. We used the mec3-dn allele, which causes a dominant negative checkpoint defect in G1 but not in G2, to test the stability of the complex in vivo and to correlate its assembly and...

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PMID: 12672803
DOI: 10.1074/jbc.M301260200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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