Article
Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination.
The EMBO journal - 1 Sept 2004
Budzowska Magda, Jaspers Iris, Essers Jeroen, de Waard Harm, van Drunen Ellen, Hanada Katsuhiro, Beverloo Berna, Hendriks Rudolf W, de Klein Annelies, Kanaar Roland, Hoeijmakers Jan H, Maas Alex
Abstract excerpt
Genetic defects in DNA repair mechanisms and cell cycle checkpoint (CCC) genes result in increased genomic instability and cancer predisposition. Discovery of mammalian homologs of yeast CCC genes suggests conservation of checkpoint mechanisms between yeast and mammals. However, the role of many CCC genes in higher eukaryotes remains elusive. Here, we report that targeted deletion of an N-terminal part of mRad17,...
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