Yeast pip3/mec3 mutants fail to delay entry into S phase and to slow DNA replication in response to DNA damage, and they define a functional link between Mec3 and DNA primase.

doi:10.1128/MCB.16.7.3235

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Article

Yeast pip3/mec3 mutants fail to delay entry into S phase and to slow DNA replication in response to DNA damage, and they define a functional link between Mec3 and DNA primase.

Molecular and cellular biology - 1 Jul 1996

Longhese M P, Fraschini R, Plevani P, Lucchini G

Abstract excerpt

The catalytic DNA primase subunit of the DNA polymerase alpha-primase complex is encoded by the essential PRI1 gene in Saccharomyces cerevisiae. To identify factors that functionally interact with yeast DNA primase in living cells, we developed a genetic screen for mutants that are lethal at the...

Topics

Cell Cycle
Cell Cycle Proteins
DNA Damage
DNA Primase
DNA Replication
Dose-Response Relationship, Radiation
Genes, Fungal
Genetic Complementation Test
Genotype
Hydroxyurea
Methyl Methanesulfonate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitosis

Mutagenesis

Mutagens

RNA Nucleotidyltransferases

S Phase

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8668138
DOI: 10.1128/MCB.16.7.3235
PMCID: PMC231317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8668138-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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