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Article

Yeast checkpoint genes in DNA damage processing: implications for repair and arrest.

Science (New York, N.Y.) - 1 Dec 1995

Lydall D, Weinert T

Abstract excerpt

Yeast checkpoint control genes were found to affect processing of DNA damage as well as cell cycle arrest. An assay that measures DNA damage processing in vivo showed that the checkpoint genes RAD17, RAD24, and MEC3 activated an exonuclease that degrades DNA. The degradation is probably a direct consequence of checkpoint protein function, because RAD17 encodes a putative 3'-5' DNA exonuclease. Another checkpoint...

Topics

Amino Acid Sequence
Cell Cycle Proteins
DNA Damage
DNA Repair
DNA, Fungal
DNA-Binding Proteins
Exonucleases
Fungal Proteins
G2 Phase
Genes, Fungal
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Yeasts

Source

Identifiers

PMID: 7491494
DOI: 10.1126/science.270.5241.1488

Genes

RAD17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7491494-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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