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Article

Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking.

PloS one - 1 Jan 2017

Royal Alice A, Tinker Andrew, Harmer Stephen C

Abstract excerpt

The slow delayed-rectifier potassium current (IKs) is crucial for human cardiac action potential repolarization. The formation of IKs requires co-assembly of the KCNQ1 α-subunit and KCNE1 β-subunit, and mutations in either of these subunits can lead to hereditary long QT syndrome types 1 and 5, respectively. It is widely recognised that the KCNQ1/KCNE1 (Q1/E1) channel requires...

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Source

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Identifiers

PMID: 29020060
DOI: 10.1371/journal.pone.0186293
PMCID: PMC5636153

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Research trail→

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Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking.PMID 29020060Read ↗

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Impaired KCNQ1-KCNE1 and phosphatidylinositol-4,5-bisphosphate interaction underlies the long QT syndrome.Semantic proximity Read ↗

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Gating and Regulation of KCNQ1 and KCNQ1 + KCNE1 Channel ComplexesSemantic proximity Read ↗

Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation.Semantic proximity Read ↗

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