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Article

A schizophrenia-linked mutation in PIP5K2A fails to activate neuronal M channels.

Psychopharmacology - 1 Jul 2008

Fedorenko Olga, Strutz-Seebohm Nathalie, Henrion Ulrike, Ureche Oana N, Lang Florian, Seebohm Guiscard, Lang Undine E

Abstract excerpt

RATIONALE: Evidence for an association between phosphatidylinositol-4-phosphate 5-kinase II alpha (PIP5K2A) and schizophrenia was recently obtained and replicated in several samples. PIP5K2A controls the function of KCNQ channels via phosphatidylinositol-4,5-bisphosphate (PIP2) synthesis. Interes...

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Source

Identifiers

PMID: 18545987
DOI: 10.1007/s00213-008-1095-x

Genes

KCNQ3
KCNQ2
KCNQ5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18545987-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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A schizophrenia-linked mutation in PIP5K2A fails to activate neuronal M channels.PMID 18545987Read ↗

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Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels.Semantic proximity Read ↗

Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia.Semantic proximity Read ↗

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