mGlu4 potentiation of K(2P)2.1 is dependant on C-terminal dephosphorylation.

Abstract excerpt

Two-pore domain potassium (K(2P)) channels are proposed to underlie the background or leak current found in many excitable cells. Extensive studies have been performed investigating the inhibition of K(2P)2.1 by Galpha(q)- and Galpha(s)-coupled G-protein-coupled receptors (GPCRs), whereas in the present study we investigate the mechanisms underlying Galpha(i)/Galpha(o)-coupled GPCR increases in K(2P)2.1 activity....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to 8-Bromo Cyclic Adenosine Monophosphate
• Share to Cricetulus