Article
Gating dependence of inner pore access in inward rectifier K(+) channels.
Neuron - 27 Mar 2003
Phillips L Revell, Enkvetchakul Decha, Nichols Colin G
Abstract excerpt
Cation channel gating may occur either at or below the inner vestibule entrance or at the selectivity filter. To differentiate these possibilities in inward rectifier (Kir) channels, we examined cysteine accessibility in the ATP-gated Kir6.2 channel. MTSEA and MTSET both block channels and modify M2 cysteines with identical voltage dependence. If entry is restricted to open channels, modification rates will slow...
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