Article
Ion currents through Kir potassium channels are gated by anionic lipids.
Nature communications - 25 Jan 2022
Jin Ruitao, He Sitong, Black Katrina A, Clarke Oliver B, Wu Di, Bolla Jani R, Johnson Paul, Periasamy Agalya, Wardak Ahmad, Czabotar Peter, Colman Peter M, Robinson Carol V, Laver Derek, Smith Brian J, Gulbis Jacqueline M
Abstract excerpt
Ion currents through potassium channels are gated. Constriction of the ion conduction pathway at the inner helix bundle, the textbook gate of Kir potassium channels, has been shown to be an ineffective permeation control, creating a rift in our understanding of how these channels are gated. Here we present evidence that anionic lipids act as interactive response elements sufficient to gate potassium conduction....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.