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Article

Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel.

Nature communications - 17 May 2016

Oelstrom Kevin, Chanda Baron

Abstract excerpt

Opening and closing of the central ion-conducting pore in voltage-dependent ion channels is gated by changes in membrane potential. Although a gate residue in the eukaryotic voltage-gated sodium channel has been identified, the minimal molecular determinants of this gate region remain unknown. Here, by measuring the closed- and open-state reactivity of MTSET to substituted cysteines in all the pore-lining...

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Identifiers

PMID: 27186888
DOI: 10.1038/ncomms11608
PMCID: PMC4873679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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