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Article

Lysophosphatidylinositol-acyltransferase-1 (LPIAT1) is required to maintain physiological levels of PtdIns and PtdInsP(2) in the mouse.

PloS one - 1 Jan 2013

Anderson Karen E, Kielkowska Anna, Durrant Tom N, Juvin Veronique, Clark Jonathan, Stephens Len R, Hawkins Phillip T

Abstract excerpt

We disrupted the gene encoding lysophosphatidylinositol-acyltransferase-1 (LPIAT1) in the mouse with the aim of understanding its role in determining cellular phosphoinositide content. LPIAT1(-/-) mice were born at lower than Mendelian ratios and exhibited a severe developmental brain defect. We compared the phospholipid content of livers and brains from LPIAT1(-/-) and LPIAT1(+/+) littermates by LC-ESI/MS. In...

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Identifiers

PMID: 23472195
DOI: 10.1371/journal.pone.0058425
PMCID: PMC3589398

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Source receipt: pubmed, retrieved 7 Sept 2026.

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