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Article

Disruption of the murine gene encoding phosphatidylethanolamine N-methyltransferase.

Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 1997

Walkey C J, Donohue L R, Bronson R, Agellon L B, Vance D E

Abstract excerpt

All nucleated cells make phosphatidylcholine via the CDP-choline pathway. Liver has an alternative pathway in which phosphatidylcholine is made by methylation of phosphatidylethanolamine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). We investigated the function of PEMT and its role in animal physiology by targeted disruption of its gene, Pempt2. A targeting vector that interrupts exon 2 was...

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Source

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Identifiers

PMID: 9371769
DOI: 10.1073/pnas.94.24.12880
PMCID: PMC24232

Genes

PEMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of the murine gene encoding phosphatidylethanolamine N-methyltransferase.PMID 9371769Read ↗

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