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Article

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion.

eLife - 25 Mar 2015

Rong Xin, Wang Bo, Dunham Merlow M, Hedde Per Niklas, Wong Jinny S, Gratton Enrico, Young Stephen G, Ford David A, Tontonoz Peter

Abstract excerpt

The role of specific phospholipids (PLs) in lipid transport has been difficult to assess due to an inability to selectively manipulate membrane composition in vivo. Here we show that the phospholipid remodeling enzyme lysophosphatidylcholine acyltransferase 3 (Lpcat3) is a critical determinant of triglyceride (TG) secretion due to its unique ability to catalyze the incorporation of arachidonate into membranes....

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Identifiers

PMID: 25806685
DOI: 10.7554/eLife.06557
PMCID: PMC4400582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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