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Article

The ACE gene and Alzheimer's disease susceptibility.

Journal of medical genetics - 1 Sept 2000

Narain Y, Yip A, Murphy T, Brayne C, Easton D, Evans J G, Xuereb J, Cairns N, Esiri M M, Furlong R A, Rubinsztein D C

Abstract excerpt

A recent study suggested that the insertion (I) allele in intron 16 of the angiotensin converting enzyme gene (ACE) is associated with Alzheimer's disease (AD) risk. In our series of 239 necropsy confirmed late onset AD cases and 342 elderly non-demented controls aged >73 years, we found significantly different ACE genotype distributions in the case and control groups (p=0.007). Homozygotes for both the I and D...

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Source

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Identifiers

PMID: 10978362
DOI: 10.1136/jmg.37.9.695
PMCID: PMC1734696

Genes

ACE
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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