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Article

An enhanced integrated stress response ameliorates mutant SOD1-induced ALS

23 Dec 2013

Abstract excerpt

Varied stresses to cells can lead to a repression in translation by triggering phosphorylation of eukaryotic translation initiator factor 2α (eIF2α), which is central to a process known as the integrated stress response (ISR). PKR-like ER-localized eIF2 kinase (PERK), one of the kinases that phosphorylates eIF2α and coordinates the ISR, is activated by stress occurring from the accumulation of misfolded or...

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PMID: 24368417
DOI: 10.1093/hmg/ddt658

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