Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives.

Abstract excerpt

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder characterized by the occurrence within a family of multiple cases of colorectal cancer in the absence of gastrointestinal polyposis. The prevalence of this syndrome is not yet clear, but it may account for 1%-5% of all colorectal cancers. Prior to the identification of the genetic basis of this syndrome, the disease was recognized...

Topics

• Colorectal Neoplasms, Hereditary Nonpolyposis
• Genetic Linkage
• Humans
• Mutation