Article
[Quasispecies and variations of hepatitis B virus: core promotor region as an example].
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology - 1 Sept 2002
Dong Jing, Cheng Jun, Wang Qinhuan, Wang Gang, Shi Shuangshuang, Liu Yan, Xia Xiaobing, Li Li, Zhang Guoqing, Si Chongwen
Abstract excerpt
OBJECTIVE: To investigate the HBV quasispecies groups in the patients with chronic HBV infection. METHODS: A set of specific primers was synthesized according to DNA sequence of HBV strain found in China. The whole core promoter (CP) region was amplified by PCR method from the sera of 3 patients with chronic HBV infection, and the PCR products were subcloned into pGEM Teasy vectors. The clones were randomly...
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