Article
[Mutations and their significance in the corepromoter region of hepatitis B virus].
Zhonghua yi xue za zhi - 1 Aug 1997
Tu H, Wen Y, Xiong S
Abstract excerpt
OBJECTIVE: To study the mutations in the core promoter (CP) region of hepatitis B virus (HBV) in Chinese viral hepatits B patients. METHODS: CP regions of 48 HBV strains were analysed by polymerase chain reaction (PCR) direct sequencing approach. RESULTS: 67% of the samples were detected to have point mutations in the CP region. The hot spots located in nt 1754-1766 and nt 1801-1811 while nucleotides in nt...
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