Article
Quasispecies groups in the core promoter region of hepatitis B virus.
Hepatobiliary & pancreatic diseases international : HBPD INT - 1 Aug 2002
Deng Hong, Dong Jing, Cheng Jun, Huangfu Kun-Jing, Shi Shuang-Shuang, Hong Yuan, Ren Xi-Min, Li Li
Abstract excerpt
OBJECTIVES: To investigate the mutation of the basic core promoter (BCP) of hepatitis B virus (HBV) and clarify the significance of HBV quasispecies groups in patients with chronic HBV infection. METHODS: A set of specific primers was synthesized according to the HBV DNA sequence of a Chinese strain. The BCP was amplified by PCR method from the serum of 40 patients with chronic HBV infection, and the PCR products...
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