Article
[The study on heterogeneity of hepatitis B virus DNA].
Zhonghua yi xue za zhi - 25 Jan 2002
Dong Jing, Cheng Jun, Wang Qinhuan, Huangfu Jingkun, Shi Shuangshuang, Zhang Guoqing, Hong Yuan, Li Li, Si Chongwen
Abstract excerpt
OBJECTIVE: To investigate the HBV quasispecies groups in the patients with chronic HBV infection. METHODS: Specific primers ware synthesized according to HBV strain found in China, the preC/C gene, reverse transcriptase region, whole S region, X gene and whole genome ware amplified by PCR method from the serum of 18 patients with chronic HBV infection, and then the PCR products were subcloned into pGEM Teasy...
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