Article
Diversity of core promoter mutations in immune clearance phase of chronic HBV infection.
European journal of gastroenterology & hepatology - 1 Aug 1999
Kim Y S, Kim S I, Hwang S G, Kim J O, Cho J Y, Lee J S, Lee M S, Hwang S D, Shim C S
Abstract excerpt
BACKGROUND/AIMS: Transcription of HBV (hepatitis B virus) pre-core and pre-genomic mRNAs is controlled by core promoter. Therefore, mutations in the core promoter region might change the activity of liver diseases through an altered transcriptional level of the mRNA. The present study was carried out to determine the diversity of HBV core promoter sequences in chronic HBV carriers. METHODS: DNA sequences in the...
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