Article
[Gene mutation in the areas of PreC/C and BCP of HBV DNA].
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology - 1 Mar 2005
Sun Cheng-long, Wang Hui-min, Wang Yue-guo, Zhang Dong-lei, Wu Yue-ping, Zhao Jian-long
Abstract excerpt
OBJECTIVE: To investigate the gene mutation in the areas of pre core/core (Pre C/C) and basic core promotor (BCP) of HBV DNA and its clinical significance. METHODS: The nt 1 735-1 965 segment of HBV DNA was amplified with PCR in 54 cases with chronic hepatitis B and 10 cases with post-hepatitis cirrhosis. Then the PCR product was sequenced. RESULTS: There were 168 site mutations in 48.5% (33/68) cases with...
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