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Article

Mutation of the murine Bloom's syndrome gene produces global genome destabilization.

Molecular and cellular biology - 1 Sept 2006

Chester Nicholas, Babbe Holger, Pinkas Jan, Manning Charlene, Leder Philip

Abstract excerpt

Bloom's syndrome (BS) is a genetic disorder characterized cellularly by increases in sister chromatid exchanges (SCEs) and numbers of micronuclei. BS is caused by mutation in the BLM DNA helicase gene and involves a greatly enhanced risk of developing the range of malignancies seen in the general...

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Source

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Identifiers

PMID: 16914751
DOI: 10.1128/MCB.00296-06
PMCID: PMC1592839

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16914751-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Mutation of the murine Bloom's syndrome gene produces global genome destabilization.PMID 16914751Read ↗

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Bloom syndrome and the underlying causes of genetic instability.Semantic proximity Read ↗

Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.Semantic proximity Read ↗

Genomic instability and cancer: lessons from analysis of Bloom's syndrome.Semantic proximity Read ↗

Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells.Semantic proximity Read ↗

Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.Semantic proximity Read ↗

Spontaneous and induced chromosomal damage and mutations in Bloom Syndrome mice.Semantic proximity Read ↗

Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks.Semantic proximity Read ↗

Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome.Semantic proximity Read ↗

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