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Article

A genome-wide library of MADM mice for single-cell genetic mosaic analysis.

Cell reports - 22 Jun 2021

Contreras Ximena, Amberg Nicole, Davaatseren Amarbayasgalan, Hansen Andi H, Sonntag Johanna, Andersen Lill, Bernthaler Tina, Streicher Carmen, Heger Anna, Johnson Randy L, Schwarz Lindsay A, Luo Liqun, Rülicke Thomas, Hippenmeyer Simon

Abstract excerpt

Mosaic analysis with double markers (MADM) offers one approach to visualize and concomitantly manipulate genetically defined cells in mice with single-cell resolution. MADM applications include the analysis of lineage, single-cell morphology and physiology, genomic imprinting phenotypes, and dissection of cell-autonomous gene functions in vivo in health and disease. Yet, MADM can only be applied to <25% of all...

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Identifiers

PMID: 34161767
DOI: 10.1016/j.celrep.2021.109274
PMCID: PMC8317686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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