Article
The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein.
Blood - 15 Jul 2003
Spierings Eric, Brickner Anthony G, Caldwell Jennifer A, Zegveld Suzanne, Tatsis Nia, Blokland Els, Pool Jos, Pierce Richard A, Mollah Sahana, Shabanowitz Jeffrey, Eisenlohr Laurence C, van Veelen Peter, Ossendorp Ferry, Hunt Donald F, Goulmy Els, Engelhard Victor H
Abstract excerpt
Minor histocompatibility (H) antigens crucially affect the outcome of human leukocyte antigen (HLA)-identical allogeneic stem cell transplantation (SCT). To understand the basis of alloimmune responses against minor H antigens, identification of minor H peptides and their antigenicity-determining mechanisms is essential. Here we report the identification of HA-3 and its encoding gene. The HA-3 peptide, VTEPGTAQY...
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