Article
A single nucleotide polymorphism in the Emp3 gene defines the H4 minor histocompatibility antigen.
Immunogenetics - 1 Aug 2003
Luedtke Brianna, Pooler Laura M, Choi Eun Young, Tranchita Angela M, Reinbold Corbett J A, Brown Aaron C, Shaffer Daniel J, Roopenian Derry C, Malarkannan Subramaniam
Abstract excerpt
Minor histocompatibility antigens (minor H antigen) elicit strong T-cell-mediated responses during both graft rejection and graft versus leukemia (GvL) among MHC-matched individuals (where MHC is major histocompatibility complex). Employing expression-cloning methodology, we have identified a cDNA clone, MI-35, encoding the immunodominant H4b minor H antigen within the classical mouse H4 complex. The minimal...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- DNA, Complementary
- Epitopes
- Isoantigens
- Membrane Glycoproteins
- Mice
- Minor Histocompatibility Antigens
- Molecular Sequence Data
- Polymorphism, Single Nucleotide