Article
SF3B1K700E Neoantigen Is a CD8+ T-cell Target Shared across Human Myeloid Neoplasms.
Cancer immunology research - 2 Sept 2025
Biernacki Melinda A, Lok Jessica, Foster Kimberly A, Cummings Carrie, Busch Stephanie, Black R Graeme, Ray Suhita, Baquero Galvis Laura, Monahan Tim, Oh Stephen T, Oehler Vivian G, Stirewalt Derek L, Wu David, Deeg H Joachim, Doulatov Sergei, Bleakley Marie
Abstract excerpt
Acquired mutations in spliceosome genes in early hematopoietic stem/progenitor cells are common events in myelodysplastic neoplasms (MDS) and related myeloid malignancies. Mutations in the spliceosome factor subunit B1 (SF3B1) gene occur in ≥20% of MDS cases at conserved hotspots and in early neoplastic clones as driver events. Neoantigens from aberrant SF3B1 proteins could serve as shared T-cell therapy targets...
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