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Article

Expression of an Ets-1 dominant-negative mutant perturbs normal and tumor angiogenesis in a mouse ear model.

Oncogene - 27 Mar 2003

Pourtier-Manzanedo Albin, Vercamer Chantal, Van Belle Eric, Mattot Virginie, Mouquet Frederic, Vandenbunder Bernard

Abstract excerpt

We and others have shown that members of the Ets family of transcription factors are involved in morphogenic properties of endothelial cells in vitro. To investigate the role of these factors in the transcriptional regulation of angiogenesis in vivo, we set up a nontraumatic model that allows daily macroscopic examination of both growth factor- and tumor-induced angiogenesis in mouse ears. In the same animal, we...

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Source

Identifiers

PMID: 12660815
DOI: 10.1038/sj.onc.1206215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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