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Article

Generation of transgenic mice overexpressing EfnB2 in endothelial cells.

Genesis (New York, N.Y. : 2000) - 1 Oct 2011

Luxey Maëva, Laussu Julien, Jungas Thomas, Davy Alice

Abstract excerpt

Genetic studies have shown that ephrin-B2 and its cognate EphB4 receptor are necessary for normal embryonic angiogenesis. Moreover, there is overwhelming evidence that ephrin-B2 is involved in tumor vascularization, yet its role in adult angiogenesis has been difficult to track genetically. Here, we report the generation of transgenic mice that over-express EfnB2 specifically in endothelial cells (ECs). We show...

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Share to Endothelial Cells
Share to Endothelium, Vascular
Share to Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neovascularization, Physiologic

Share to Promoter Regions, Genetic

Share to Receptor Protein-Tyrosine Kinases

Share to Receptor, TIE-2

Share to Signal Transduction

Source

Identifiers

PMID: 21735541
DOI: 10.1002/dvg.20785

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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