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Article

Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors

14 Feb 2005

Abstract excerpt

Disruption of the systemic angiogenesis balance to favor enhanced angiogenesis is speculated to represent a key step in the growth of tumors. Although a major emphasis has been placed on the increase of angiogenesis stimulators, such as VEGF, on the disruption of the angiogenic balance, the potential role of the physiological levels of endogenous inhibitors of angiogenesis on tumor growth is poorly understood....

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PMID: 15710885
DOI: 10.1073/pnas.0500180102

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