Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Embryonic lethality in Dear gene-deficient mice: new player in angiogenesis.

Physiological genomics - 17 Nov 2005

Herrera Victoria L M, Ponce Lorenz R B, Bagamasbad Pia D, VanPelt Benjamin D, Didishvili Tamara, Ruiz-Opazo Nelson

Abstract excerpt

The dual endothelin-1/angiotensin II receptor (Dear) binds endothelin-1 (ET-1) and angiotensin II (ANG II) with equal affinities in the Dahl S/JRHS rat strain. To elucidate its physiological significance within the context of multiple receptor isoforms and diverse ET-1 and ANG II functions spanning blood pressure regulation, tumor proliferation, and angiogenesis, we characterized mouse Dear and Dear-deficient...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cloning, Molecular
Share to Embryonic Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Mutant Strains

Share to Neovascularization, Physiologic

Share to Pregnancy

Share to Receptors, Angiotensin

Share to Receptors, Endothelin

Share to Restriction Mapping

Source

Identifiers

PMID: 16293765
DOI: 10.1152/physiolgenomics.00144.2005

Genes

ANG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Embryonic lethality in Dear gene-deficient mice: new player in angiogenesis.PMID 16293765Read ↗

Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding.Semantic proximity Read ↗

Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse ModelsSemantic proximity Read ↗

The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular researchSemantic proximity Read ↗

Vasculogenesis and Angiogenesis in VEGF Receptor-1 Deficient Mice.Semantic proximity Read ↗

Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesisSemantic proximity Read ↗

Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy.Semantic proximity Read ↗

Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development.Semantic proximity Read ↗

Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions.Semantic proximity Read ↗

Expression of the growth factor progranulin in endothelial cells influences growth and development of blood vessels: a novel mouse model.Semantic proximity Read ↗

VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sproutingSemantic proximity Read ↗

Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo.Semantic proximity Read ↗

Expression of an Ets-1 dominant-negative mutant perturbs normal and tumor angiogenesis in a mouse ear model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.