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Article

Angiogenesis inhibition by transdominant mutant Ets-1.

Journal of cellular physiology - 1 Aug 2000

Nakano T, Abe M, Tanaka K, Shineha R, Satomi S, Sato Y

Abstract excerpt

The expression of transcription factor Ets-1 is induced in endothelial cells (ECs) by angiogenic factor; and in turn Ets-1 converts ECs to angiogenic invasive phenotype. In order to control angiogenesis, we constructed a transdominant mutant Ets-1 (TMEts-1) which acts as a dominant negative molecule. This molecule inhibited the DNA binding and the transactivation activity of the wild-type Ets-1. Stable...

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PMID: 10867651
DOI: 10.1002/1097-4652(200008)184:2<255::AID-JCP14>3.0.CO;2-J

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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