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Article

Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis

1 Dec 2017

Abstract excerpt

Angiogenesis inhibitors are important for cancer therapy, but clinically approved anti-angiogenic agents have shown only modest efficacy and can compromise wound healing. This necessitates the development of novel anti-angiogenesis therapies. Here, we show significantly increased EGFL6 expression in tumor versus wound or normal endothelial cells. Using a series of in vitro and in vivo studies with orthotopic and...

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Identifiers

PMID: 29212026
DOI: 10.1016/j.celrep.2017.11.020

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