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Article

Fractional allele loss is a valuable marker for human lung cancer detection in sputum.

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2003

Arvanitis Demetrios A, Papadakis Emmanuel, Zafiropoulos Alexander, Spandidos Demetrios A

Abstract excerpt

Using PCR-based microsatellite DNA analysis with 48 markers we examined sputum and bronchial washing for genetic alterations compared with lymphocyte extracted DNA from 124 lung cancer patients and 36 healthy donors as normal control. Microsatellite alterations (MA) in at least one locus were detected in all cancer patient-derived specimens but only in 22.2% of the healthy donors. Loss of heterozygosity (LOH) was...

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Identifiers

PMID: 12660007
DOI: 10.1016/s0169-5002(02)00531-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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