Article
Microsatellite DNA instability and loss of heterozygosity in bronchial asthma.
The European respiratory journal - 1 Dec 2003
Paraskakis E, Sourvinos G, Passam F, Tzanakis N, Tzortzaki E G, Zervou M, Spandidos D, Siafakas N M
Abstract excerpt
Genetic alterations, such as loss of heterozygosity (LOH) or microsatellite instability (MI), have been reported in both malignant and benign disorders. In order to identify loci of deoxyribonucleic acid (DNA) mutation in asthma, MI and LOH were studied in sputum cells. DNA was extracted from cells in the sputum and blood cells of 22 patients with moderate asthma. Cells were analysed for MI and LOH using 18...
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