Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of heterozygosity in epithelial cells obtained by bronchial brushing: clinical utility in lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 1999

Powell C A, Klares S, O'Connor G, Brody J S

Abstract excerpt

To determine whether loss of heterozygosity (LOH) could be a useful diagnostic test for lung cancer, we evaluated LOH in cells obtained from bronchial brushings. Cells from radiographically normal and abnormal lungs were obtained from 55 patients undergoing diagnostic bronchoscopy. Among 38 patients with lung cancer, LOH was present in at least one chromosomal locus in 79%, whereas cytology was positive for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bronchi
Share to Carcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 11

Share to Chromosomes, Human, Pair 3

Share to Chromosomes, Human, Pair 9

Share to Epithelial Cells

Share to Loss of Heterozygosity

Share to Smoking

Source

Identifiers

PMID: 10473082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of heterozygosity in epithelial cells obtained by bronchial brushing: clinical utility in lung cancer.PMID 10473082Read ↗

Molecular changes in the bronchial epithelium of patients with small cell lung cancer.Semantic proximity Read ↗

Fractional allele loss is a valuable marker for human lung cancer detection in sputum.Semantic proximity Read ↗

Multiple high-grade bronchial dysplasia and squamous cell carcinoma: concordant and discordant mutations.Semantic proximity Read ↗

Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.Semantic proximity Read ↗

Loss of heterozygosity and the smoking index increase with decrease in differentiation of lung adenocarcinomas: etiologic implications.Semantic proximity Read ↗

Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancerSemantic proximity Read ↗

Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer.Semantic proximity Read ↗

Analysis of loss of heterozygosity in atypical and negative bile duct brushing cytology specimens with malignant outcome: are "false-negative" cytologic findings a representation of morphologically subtle molecular alterations?Semantic proximity Read ↗

High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints.Semantic proximity Read ↗

Multiple genetic and epigenetic biomarkers for lung cancer detection in cytologically negative sputum and a nested case–control study for risk assessmentSemantic proximity Read ↗

Loss of heterozygosity in ductal lavage for breast tumor and the contralateral breast.Semantic proximity Read ↗

Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.