Article
Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2003
Gordon Melinda S, Kanegai Cindy M, Doerr Jeanette R, Wall Randolph
Abstract excerpt
Somatic hypermutation (SHM), coupled to selection by antigen, generates high-affinity antibodies during germinal center (GC) B cell maturation. SHM is known to affect Bcl6, four additional oncogenes in diffuse large B cell lymphoma, and the CD95Fas gene and is regarded as a major mechanism of B cell tumorigenesis. We find that mutations in the genes encoding the B cell receptor (BCR) accessory proteins B29...
Topics
- Antigens, CD
- B-Lymphocytes
- CD79 Antigens
- Cell Line
- Cells, Cultured
- Genes, Immunoglobulin
- Humans
- Lymphoma, B-Cell
- Multiple Myeloma
- Mutation
- Oncogenes
- Polymerase Chain Reaction
- Receptors, Antigen, B-Cell
- Reverse Transcriptase Polymerase Chain Reaction