Article
DNA repair genes are selectively mutated in diffuse large B cell lymphomas.
The Journal of experimental medicine - 26 Aug 2013
de Miranda Noel F C C, Peng Roujun, Georgiou Konstantinos, Wu Chenglin, Falk Sörqvist Elin, Berglund Mattias, Chen Longyun, Gao Zhibo, Lagerstedt Kristina, Lisboa Susana, Roos Fredrik, van Wezel Tom, Teixeira Manuel R, Rosenquist Richard, Sundström Christer, Enblad Gunilla, Nilsson Mats, Zeng Yixin, Kipling David, Pan-Hammarström Qiang
Abstract excerpt
DNA repair mechanisms are fundamental for B cell development, which relies on the somatic diversification of the immunoglobulin genes by V(D)J recombination, somatic hypermutation, and class switch recombination. Their failure is postulated to promote genomic instability and malignant transformation in B cells. By performing targeted sequencing of 73 key DNA repair genes in 29 B cell lymphoma samples, somatic and...
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