Article
Defective platelet activation in G alpha(q)-deficient mice.
Nature - 11 Sept 1997
Offermanns S, Toombs C F, Hu Y H, Simon M I
Abstract excerpt
Platelets are small disc-shaped cell fragments which undergo a rapid transformation when they encounter vascular damage. They become more spherical and extrude pseudopodia, their fibrinogen receptors are activated, causing them to aggregate, they release their granule contents, and eventually form a plug which is responsible for primary haemostasis. Activation of platelets is also implicated in the pathogenesis...
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