Article
Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 1995
Moser A R, Shoemaker A R, Connelly C S, Clipson L, Gould K A, Luongo C, Dove W F, Siggers P H, Gardner R L
Abstract excerpt
Mutation of the APC (adenomatous polyposis coli) gene is an early event in colon tumor development in humans. Mice carrying Min (multiple intestinal neoplasia), a mutant allele of Apc, develop intestinal and mammary tumors as adults. To study the role of the Apc gene in development, we have investigated the phenotype of embryos homozygous for ApcMin (Min). Development of the primitive ectoderm fails prior to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.