Article
Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 1995
Moser A R, Shoemaker A R, Connelly C S, Clipson L, Gould K A, Luongo C, Dove W F, Siggers P H, Gardner R L
Abstract excerpt
Mutation of the APC (adenomatous polyposis coli) gene is an early event in colon tumor development in humans. Mice carrying Min (multiple intestinal neoplasia), a mutant allele of Apc, develop intestinal and mammary tumors as adults. To study the role of the Apc gene in development, we have inves...
Topics
- Alleles
- Animals
- Embryo, Mammalian
- Gastrula
- Genes, APC
- Genes, Lethal
- Genotype
- Heterozygote
- Homozygote
- Mice
- Mice, Inbred Strains
- Mutation
- Phenotype