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Article

Catalytic properties of mutant 23 S ribosomes resistant to oxazolidinones.

The Journal of biological chemistry - 14 Mar 2003

Bobkova Ekaterina V, Yan Yong Ping, Jordan Douglas B, Kurilla Michael G, Pompliano David L

Abstract excerpt

Kinetic analysis of ribosomal peptidyltransferase activity in a methanolic puromycin reaction with wild type and drug-resistant 23 S RNA mutants was used to probe the structural basis of catalysis and mechanism of resistance to antibiotics. 23 S RNA mutants G2032A and G2447A are resistant to oxazolidinones both in vitro and in vivo with the latter displaying a 5-fold increase in the value of Km for initiator tRNA...

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Share to RNA, Ribosomal, 23S
Share to Antibiotics, Antineoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Peptidyl Transferases

Share to Protein Synthesis Inhibitors

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Source

Identifiers

PMID: 12645571
DOI: 10.1074/jbc.m209249200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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