Article
Mutations in the bacterial ribosomal protein l3 and their association with antibiotic resistance.
Antimicrobial agents and chemotherapy - 1 Jan 2015
Klitgaard Rasmus N, Ntokou Eleni, Nørgaard Katrine, Biltoft Daniel, Hansen Lykke H, Trædholm Nicolai M, Kongsted Jacob, Vester Birte
Abstract excerpt
Different groups of antibiotics bind to the peptidyl transferase center (PTC) in the large subunit of the bacterial ribosome. Resistance to these groups of antibiotics has often been linked with mutations or methylations of the 23S rRNA. In recent years, there has been a rise in the number of studies where mutations have been found in the ribosomal protein L3 in bacterial strains resistant to PTC-targeting...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.