Article
Ribosomal protein L3: influence on ribosome structure and function.
RNA biology - 1 May 2004
Petrov Alexey, Meskauskas Arturas, Dinman Jonathan D
Abstract excerpt
Early studies demonstrated roles for ribosomal protein L3 in peptidyltransferase center formation and the ability of cells to propagate viruses. More recent studies have linked these two processes via the effects of mutants and drugs on programmed -1 ribosomal frameshifting. Here, we show that mutant forms of L3 result in ribosomes having increased affinities for both aminoacyl- and peptidyl-tRNAs. These defects...
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