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Article

Resistance to the peptidyl transferase inhibitor tiamulin caused by mutation of ribosomal protein l3.

Antimicrobial agents and chemotherapy - 1 Sept 2003

Bøsling Jacob, Poulsen Susan M, Vester Birte, Long Katherine S

Abstract excerpt

The antibiotic tiamulin targets the 50S subunit of the bacterial ribosome and interacts at the peptidyl transferase center. Tiamulin-resistant Escherichia coli mutants were isolated in order to elucidate mechanisms of resistance to the drug. No mutations in the rRNA were selected as resistance determinants using a strain expressing only a plasmid-encoded rRNA operon. Selection in a strain with all seven...

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Identifiers

PMID: 12936991
DOI: 10.1128/AAC.47.9.2892-2896.2003
PMCID: PMC182624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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