Article
Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic.
Antimicrobial agents and chemotherapy - 1 May 2012
Grossman Trudy H, Starosta Agata L, Fyfe Corey, O'Brien William, Rothstein David M, Mikolajka Aleksandra, Wilson Daniel N, Sutcliffe Joyce A
Abstract excerpt
TP-434 is a novel, broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major antibiotic resistance mechanisms, including tetracycline-specific efflux and ribosomal protection. The mechanism of action of TP-434 was assessed using both cell-based and in vitro assays. In Escherichia coli cells expressing recombinant tetracycline resistance genes, the MIC of TP-434 (0.063 μg/ml) was...
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