Article
Correlation of cytochrome P450 (CYP) 1A2 activity using caffeine phenotyping and olanzapine disposition in healthy volunteers.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2003
Shirley Kara Lee, Hon Yuen Y, Penzak Scott R, Lam Y W Francis, Spratlin Vicky, Jann Michael W
Abstract excerpt
Olanzapine has previously been shown to have predominant metabolism by cytochrome (CYP) P450 1A2. Caffeine has been shown to provide an accurate phenotypic probe for measuring CYP1A2 activity. The purpose of this study is to determine if a significant correlation exists between olanzapine disposition and caffeine metabolic ratios. Subjects were phenotyped for CYP1A2 activity with caffeine probe methodology. After...
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