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Article

In Vitro Characterization of the Human Liver Microsomal Kinetics and Reaction Phenotyping of Olanzapine Metabolism.

Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2015

Korprasertthaworn Porntipa, Polasek Thomas M, Sorich Michael J, McLachlan Andrew J, Miners John O, Tucker Geoffrey T, Rowland Andrew

Abstract excerpt

Olanzapine (OLZ) is an atypical antipsychotic used in the treatment of schizophrenia and related psychoses. The metabolism of OLZ is complex and incompletely characterized. This study aimed to elucidate the enzymes and pathways involved in the metabolism of OLZ and to determine the kinetics of OLZ oxidation and glucuronidation by human liver microsomes, recombinant cytochrome P450 (rP450) enzymes, and recombinant...

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Identifiers

PMID: 26329789
DOI: 10.1124/dmd.115.064790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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